The Efficacy of the Czech Original Prophylactic Mixture, Called Panpal, as Pharmacological Pretreatment of Tabun or Soman-Poisoned Rats and Mice
Abstract
The potency of the Czech original pharmacological pretreatment consisting of pyridostigmine, benactyzine and trihexyphenidyle, designated PANPAL, to increase the resistance of rats and mice against tabun or soman and to increase the therapeutic efficacy of standard antidotal treatment of tabun or soman-poisoned experimental animals was studied and compared with commonly used pyridostigmine alone. While PANPAL significantly increased the resistance of animals against tabun or soman and increased the efficacy of currently used antidotal treatment of tabun or soman poisoning, pyridostigmine alone was not able to sufficiantly protect experimental animals against tabun or soman-induced acute toxicity. Our findings confirm that PANPAL, lincensed and introduced to the Czech Army, seems to be promising and beneficial pharmacological pretreatment in the case of the threat of exposure to nerve agents, especially tabun or soman. It appears to be more suitable than currently used pyridostigmine alone.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2005
- Accession Number
- ADA449748
Entities
People
- Gabriela Krejcova
- Jiri Bajgar
- Jiri Kassa
- Josef Fusek
- Lucie Sevelova