Interactions of Organophosphorus and Related Compounds with Acetylcholinesterase

Abstract

The objective of this study was to understand the reversible and irreversible binding of organophosphorus (OP) and other compounds in active site of acetylcholinesterase, the role of solvent, the mechanism of oxime therapy and the "aging" mechanism through the use of theoretical modeling in order to facilitate development of new compounds for therapeutic and prophylaxis.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2005
Accession Number
ADA449773

Entities

People

  • Gerald Lushington
  • Jeffrey B. Wright
  • Margaret M. Hurley

Organizations

  • United States Army Research Laboratory

Tags

Communities of Interest

  • Human Systems

DTIC Thesaurus Topics

  • Abstracts
  • Acetylcholinesterases
  • Charge Transfer
  • Chemical Compounds
  • Enzymes
  • Information Operations
  • Information Science
  • Instructions
  • Migration
  • Military Research
  • Orientation (Direction)
  • Preventive Medicine
  • Reversible
  • Sensitivity
  • Therapy
  • Universities

Fields of Study

  • Agricultural and Food sciences
  • Chemistry

Readers

  • Neurotoxicology
  • Quantum Chemistry