In vitro Characterization of Recombinant Human BuChE (Protexia) as a Potential Bioscavenger

Abstract

OBJECTIVES: (1) Demonstrate improved medical protection against nerve agents; (2) Develop a prophylactic that detoxifies nerve agents at a rate sufficient to protect against 5LD-50 exposure; (3) Prophylactic should: Be non-toxic - Product no adverse side effects - Have no adverse effect on performance - Be easy to administer - Have a long biological half-life. CONCEPT: Provide a pretreatment capable of protecting against up to 5xLD-50 of nerve agent with no side effects and no need for additional protective clothing or therapy.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2005
Accession Number
ADA449783

Entities

People

  • Akrati Saxena
  • B. P. Doctor
  • C. N. Karatzas
  • D. M. Cerasoli
  • David E. Lenz
  • E. M. Griffiths
  • H. Wilgus
  • N. H. Greig
  • Q. S. Yu
  • Yihe Huang

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Biotechnology
  • Chemistry
  • Clothing
  • Information Operations
  • Inhibitors
  • Materials
  • Molecular Biology
  • Nerve Agents
  • Protective Clothing
  • Pyridostigmine Bromide
  • Side Effects
  • Three Dimensional

Fields of Study

  • Medicine

Readers

  • Neurotoxicology
  • Systems Analysis and Design
  • Toxicology/Environmental Toxicology