Investigating Toxicity and Differential Protein Expression in the Aedes aegypti Mosquito Larvae, as an in vivo Bioassay for Chemical and Biological Weapon Agents

Abstract

What sets this detection method apart from others? (1) Currently, detection systems for biological warfare agents utilize PCR (polymerase chain reaction) to amplify genetic material specific to an agent, or antibodies that recognize proteins specific for known agents; (2) Current detection systems for chemical warfare agents utilize physical and chemical properties that are specific for known agents; (3) In the IAD system, we are measuring the response of an organism to an agent, or class of agents. Inherent in this, is that our antibodies detect proteins that are in the insect, and their translational/post-translational alteration after exposure to an environmental sample; (4) So far, the proteins that are responsive to insult with chem/bio agents are agent and dose specific.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2005
Accession Number
ADA449799

Entities

People

  • A. Rayms-keller
  • B. W. Gutting
  • R. S. Mackie

Organizations

  • Naval Surface Warfare Center

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Assays
  • Bioassay
  • Biological Warfare
  • Biological Warfare Agents
  • Biological Weapons
  • Chain Reactions
  • Chemical Properties
  • Chemical Warfare
  • Chemical Warfare Agents
  • Detection
  • Infectious Diseases
  • Materials
  • Polymerase Chain Reaction
  • Toxicity
  • Warfare
  • Weapons

Readers

  • Critical Infrastructure Protection in CBRN and WMD Threats.
  • Molecular Genetics
  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology