Use of DNA Microarrays to Identify Diagnostic Signature Transcriptional Profiles for Host Responses to Infectious Agents
Abstract
Infections by agents of bioterrorism, especially bacterial agents such as Bacillus anthracis and Yersinia pestis present their initial symptoms in a way that does not reveal their identity or permit rapid diagnosis. However, as was shown in the recent anthrax attacks on the United States, rapid diagnosis can make the difference between life and death for the patient. Bacteria especially virulent bacteria, have a profound effect on the immune system of the human host. Cellular and physiological studies have shown that while many similarities exist in the host immune response to bacterial infection, there are distinctive features that represent classes of organism and, in some cases, individual organisms themselves. The current proposal was designed to use advanced techniques in molecular analysis to analyze the effect of individual biothreat agents on the human immune system.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2005
- Accession Number
- ADA449913
Entities
People
- E. Raveche
- G. Gallagher
- J. J. Ellner
- N. D. Connell
Organizations
- New Jersey Medical School