Topical Application of Liposomal Antioxidant's for Protection Against CEES Induced Skin Damage

Abstract

The objective of this study is to develop an effective prophylactic therapy against an analog of mustard gas 2-chloroethylethyl sulfide (CEES). The therapy for CEES-induced skin damage will be based on the topical application of antioxidant liposomes. We will use EpiDerm cultured human skin tissues as well as cultured keratinocytes as working models. HD/CEES-induced pathophysiology involves oxidative stress. Liposomes containing both water- and lipid-soluble antioxidants are expected to be an effective antidote/therapeutic product to protect US military and civilians from a chemical warfare agent such as HD. The therapeutic efficacy as well as the chemical and physical stability of various antioxidant liposome formulations will be examined to determine the optimal preparation for future testing in animal models.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2006
Accession Number
ADA449955

Entities

People

  • Hongsong Yang
  • Min Qui
  • Victor Paromov
  • William L. Stone

Organizations

  • East Tennessee State University

Tags

DTIC Thesaurus Topics

  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemistry
  • Free Radicals
  • Health Services
  • Lung Diseases
  • Macrophages
  • Medical Personnel
  • Membrane Lipids
  • Mustard Agents
  • Oxidative Stress
  • Proteins
  • Vitamin E

Readers

  • Geochemistry
  • Immunology and Pathology
  • Systems Analysis and Design