Algorithmic Tools and Computational Frameworks for Cell Informatics

Abstract

The central thesis motivating this research project was that, by drawing upon mathematical approaches developed in the context of dynamical systems, kinetic analysis, computational theory and logic, it is possible to create powerful simulation, analysis and reasoning tools for working biologists. These tools could be used in deciphering existing data, devising new experiments and ultimately, understanding functional properties of genomes, proteomes, cells, organs and organisms. Through tool development (Simpathica, XSSYS, & GOALIE), analysis of important biological systems (apoptosis, purine metabolism, cell cycle, host-pathogen interaction, etc.) and foundational mathematical and algorithmic research (algebraic algorithm model checking, hidden Kripke model, best basis description, etc.), this project has succeeded in bring systems biology closer to its goals.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2006
Accession Number
ADA450190

Entities

People

  • Bhubaneswar Mishra

Organizations

  • New York University

Tags

DTIC Thesaurus Topics

  • Air Force Research Laboratories
  • Algorithms
  • Apoptosis
  • Cell Physiological Processes
  • Cells
  • Computational Biology
  • Computational Science
  • Computers
  • Data Analysis
  • Data Sets
  • Databases
  • Fungi
  • Genetics
  • Graphical User Interface
  • Proteins
  • Stem Cells
  • Systems Biology

Readers

  • Distributed Systems and Data Platform Development
  • Mathematical Modeling and Probability Theory.
  • Molecular Genetics

Technology Areas

  • Biotechnology