Objective Markers of Postural Instability in Parkinson's Disease

Abstract

The purpose and scope of this proposal was to identify markers of postural instability associated with PD and to relate the objective measures of postural instability to clinical ratings of PD severity. Postural sway of PD patients was quantified using an array of linear and nonlinear measures. For H-Y Stage 2 patients postural sway variability and stationarity were able to differentiate PD patients from age-matched controls. For H-Y Stage 3, sway variability differentiated PD patients and controls. There was only one significant correlation, which was between the UPDRS posture score and the nonlinear measure of non- stationarity in the anterior-posterior direction. In spite of the limited sensitivity of the individual measures, stepwise regression revealed four postural sway measures that significantly predicted H-Y stage (anterior-posterior sway variability, sway path length, sway pattern complexity, and sway nonstationarity). Sway variability (AP) and sway nonstationarity significantly predicted the UPDRS posture scores. Those findings suggest PD severity may be objectively classified using multiple indices of postural sway activity.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2005
Accession Number
ADA450488

Entities

People

  • Kevin D. Shockley
  • Michael A. Riley

Organizations

  • University of Cincinnati

Tags

Communities of Interest

  • Human Systems
  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Behavioral Sciences
  • Brain
  • Control Systems
  • Data Analysis
  • Diseases And Disorders
  • Health Services
  • Information Science
  • Medical Personnel
  • Movement Disorders
  • Neural Networks
  • Neurology
  • Nonlinear Dynamics
  • Parkinson'S Disease
  • Psychology
  • Three Dimensional

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