Effects of Hematopoietic Stem Cell Age on CML Disease Progression
Abstract
CML results from a chromosomal translocation in hematopoietic stem cells (HSC), yet the disease primarily presents as a myeloid hyperplasia with relatively infrequent lymphoid involvement. We proposed that age-associated defects in the potential of HSC to generate lymphocytes underlies this presentation. The results at the time of this writing support this hypothesis. Bone marrow cells from young and old mice were transduced with a retrovirus carrying the BCR-ABL 9:22 chromosomal translocation and then transplanted into young recipients. The data indicate that recipients of the young,transduced bone marrow cells presented with myeloid and lymphoid leukemias. In contrast, recipients of old, transduced bone marrow developed leukemia with infrequent lymphoid involvement. Ongoing studies are aimed at identifying the leukemia stem cells in the young and old bone marrow.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2006
- Accession Number
- ADA451341
Entities
People
- Kenneth Dorshkind
Organizations
- University of California, Los Angeles