Cord Blood Stem Cell Procurement in Minority Donors
Abstract
This progress report summarizes the clinical activity of cord blood procurement and the preliminary analysis of the yield of the cord blood cells for the purpose of clinical transplantation. The purpose of collection and procurement of cord blood is for public use and will be accessible to all the stem cell transplantation centers worldwide. Cord blood is a readily available source of hematopoietic stem cells that is more accessible than other lived donors, since the cryopreserved cord blood units (CBU) have already been extensively characterized in term of tissue typing and screening for infectious disease markers. The CBU from minority donor, especially African/American, is particularly valuable because of difficulty with finding a matched donor and CBU allows less stringent matching. Thus, CBU is a rapid solution to patients who are in urgent need of stem cell transplantation and no living donor available. Our preliminary analysis of the collected CBUs shows significantly lower content of nucleated cells in CBUs from African/American mothers. We have not identified adverse maternal health variables associated with lower cell dose. Improvement of availability of CBUs will have to come from increase recruitment of donors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2006
- Accession Number
- ADA451380
Entities
People
- Voravit Ratanatharathorn
Organizations
- Wayne State University