Molecular Characterization of Prostate Cancer Cell Oncolysis by Herpes Simplex Virus ICP0 Mutants

Abstract

This final report outlines the progress made on our Exploration: Hypothesis Development Award over the past 18 months. Briefly, the goals of the proposal were to characterize the oncolytic capacity of Herpes simplex virus type 1 ICP0 mutants in prostate cancer cells given the relationship between ICP0 and two tumor suppressors, RNase L and PML, implicated in prostate cancer progression. We recently published that ICP0 prevents an RNase L-independent rRNA degradation event in infected cells (Journal of Virology, 2006). We also provide preliminary evidence that suggests that the ability of ICP0-null HSV-1 mutants to selectively kill prostate cancer cells correlates with both a reduction in PML levels and the status of interferon signaling within each cancer line.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2006
Accession Number
ADA451386

Entities

People

  • Karen Mossman

Organizations

  • McMaster University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cell Line
  • Chemistry
  • Cytokines
  • Degradation
  • Epithelial Cells
  • Interferon
  • Kinetics
  • Molecules
  • Neoplasms
  • Oncolytic Viruses
  • Prostate
  • Prostate Cancer
  • Proteins
  • Therapy
  • Virology
  • Viruses

Readers

  • Molecular Biology and Genetics
  • Virology (or Medical Virology).