The Impact of Exercise on the Vulnerability of Dopamine Neurons to Cell Death in Animal Models of Parkinson's Disease

Abstract

Parkinson's disease (PD) results in part from the loss of dopamine (DA) neurons. We hypothesize that exercise reduces the vulnerability of DA neurons to neurotoxin exposure, whereas stress increases vulnerability. We have outlined experiments to test this hypothesis in rats treated with one of several neurotoxins, beginning with 6- hydroxydopamine (6-OHDA). Over the past year, we increased the size and training of our research team and made a number of observations of direct relevance to our hypothesis. We also have requested permission to expand our objectives to include critical studies on the mechanism of the actions of exercise, using both in vivo and in vitro approaches. Our focus will be on the actions of trophic factors and the roles played by intracellular signaling cascades.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2005
Accession Number
ADA451406

Entities

People

  • Amanda Smith
  • Michael J. Zigmond

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Brain
  • Cell Line
  • Cell Physiological Processes
  • Diseases And Disorders
  • Dopamine
  • Liquid Chromatography
  • Neurodegeneration
  • Neurosciences
  • Neurotoxins
  • Oxidative Stress
  • Parkinson'S Disease
  • Toxins
  • Training
  • Vulnerability

Fields of Study

  • Biology

Readers

  • Economics
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.
  • Neuroscience