Neural, Endocrine and Local Mechanisms in the Effects of Environmental Stressors on the Cardiovascular Response to Blood Loss
Abstract
Our studies have provided important, new information about the role of neurohumoral systems as well as the interaction of these systems with local mechanisms in cardiovascular control during blood loss. Although, blood loss surely alters and compromises the highly integrated cardiovascular and respiratory control of oxygen delivery and removal of carbon dioxide, there is little if any published information related to respiratory control during blood loss in conscious animals. We have done experiments to define respiratory changes during a hypotensive hemorrhage in our conscious rabbit model. Finally, despite the presence of painful sensory stimuli during most traumatic blood loss, there does not appear to be any published information related to the effects of simultaneous painful sensory stimuli on cardiorespiratory control during blood loss. Our initial experiments in this area have provided a firm starting point for further studies evaluating the mechanisms involved in the effects of visceral pain on cardiovascular control in general and during hypotensive blood loss in particular.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2006
- Accession Number
- ADA452018
Entities
People
- James C. Schadt
Organizations
- Curators of the University of Missouri