Low Level Exposure to Sulfur Mustard: Development of a SOP for Analysis of Albumin Adducts and of a System for Non-Invasive Diagnosis on Skin
Abstract
Several methods for diagnosis of exposure to chemical warfare agents and other noxious compounds have been transferred to Centers for Disease Control & Prevention. 1) The modified Edman degradation of sulfur mustard-modified hemoglobin; 2) The method for diagnosis of exposure to Lewisite; 3) The method for diagnosis of exposure to phosgene In addition, a number of existing methods have been improved: 4) The albumin tripeptide assay for diagnosis of exposure to sulfur mustard; 5) The rapid assay for determination of exposure to nerve agents, based on pepsin digestion of human butyrylcholinesterase In order to circumvent the shortcomings of the current (specific) assays for diagnosis of exposure to OP-anticholinesterases, a generic method for detection of covalently modified human butyrylcholinesterase has been undertaken. Finally, various reference compounds have been synthesized and delivered to CDC.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2005
- Accession Number
- ADA452293
Entities
People
- Daan Noort
Organizations
- Prins Maurits Laboratorium TNO