The Role of the Y-Located TSPY Gene in Prostatic Oncongenesis
Abstract
The TSPY gene is the only functional gene within the critical region harboring the gonadoblastoma locus on the Y chromosome (GBY). Expression studies demonstrated that it is aberrantly expressed in prostate cancer. This project is designed to address the role of this putative oncogene on the Y chromosome in this male-specific cancer. The objectives are: 1) to identify the oncogenic or tumor promoting domain in TSPY, and 2)to correlate TSPY over-expression with prostatic oncogenesis in transgenic mice. For the past year, we have examined the TSPY expression in additional 61 cases of prostate cancer and demonstrated that its expression is proportional to the degrees of malignancy of these clinical samples. Similar study of a tissue recombination model of prostate cancer demonstrated the same results, suggesting TSPY expression is intimately associated with prostate cancer. Significantly, studies of a line of transgenic mice harboring 50 copies of the human TSPY gene on their Y chromosome demonstrated that TSPY is expressed in hyperplasic regions of the prostates of old mice, resembling those of latent cancer in old men. These findings are significant, supporting the role of TSPY in the initiation of prostatic oncogenesis. For the next 12-month period, we plan to continue our characterization of our transgenic mice to confirm TSPY as an oncogene.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2006
- Accession Number
- ADA452367
Entities
People
- Yun-fai C. Lau
Organizations
- Northern California Institute for Research and Education