Specific Reversible Cytostatic Protection of Normal Cells Against Chemotherapeutics in Breast Cancer Therapy

Abstract

The adverse effects of cancer chemotherapy are widely recognized. Hair loss,gastrointestinal discomfort, lethargy and anorexia are quite common. The cause for these events is the nonspecific nature of current cancer treatment agents. Cytotoxic drugs, while effective at killing proliferating tumor cells, also target normal dividing cells. It is the purpose of this study to develop a proven in vitro strategy to protect normal dividing cells using a cytostatic agent, UCN-01. The reversible arrest of normally dividing tissues in mice will be examined for improved tolerance of chemotherapeutics. This protective effect will also be evaluated in mice bearing orthotopically implanted breast tumors.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2006
Accession Number
ADA452368

Entities

People

  • Benjamin B. Mull

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemotherapeutic Agents
  • Chemotherapy
  • Cultured Cells
  • Department Of Defense
  • Information Operations
  • Kinetics
  • Neoplasms
  • Reversible
  • Side Effects
  • Therapy

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Oncology (Cancer Research).
  • Toxicology/Environmental Toxicology