SDF-1, DC1/DC2, and Tumor Angiogenesis

Abstract

Angiogenesis is essential for both primary and metastatic tumor growth. A number of molecules have been identified in this process. Early clinical trials with anti-angiogenic molecules, however, have not demonstrated significant benefits predicted from preclinical models. In the last 3 years, we have focused on human ovarian carcinomas and studied ovarian cancer associated dendritic cell subsets (DC1 and DC2) and chemokine SDF-1, and their contribution to tumor angiogenesis. We observed that the balance of DC subset distribution and functions in the tumor environment is relevant to tumor angiogenesis. Tumor DC2 induce tumor angiogenesis, whereas DC1 inhibit tumor angiogenesis. Ovarian tumors manipulate DC subpopulation distributions and functions by producing SDF-1 to favor tumor angiogenesis. Tumor VEGF and SDF-1 synergistically form a novel angiogenic pathway. Targeting this pathway may be applicable to development of antiangiogenesis therapies.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2006
Accession Number
ADA452370

Entities

People

  • Weiping Zou

Organizations

  • Tulane University of Louisiana

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Blood
  • Blood Vessels
  • Breast Cancer
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Epithelial Cells
  • Lymphatic System
  • Lymphocytes
  • Oncology
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Tumor Cell Line

Fields of Study

  • Biology
  • Medicine

Readers

  • Electrical Engineering
  • Oncology (Cancer Research).