Interaction of AIB1 and BRCA1 in the Development of Breast Cancer

Abstract

AIB1 (SRC3) belongs to the p160 family of steroid receptor coactivators including SRC-1 and SRC-2. AIB1 interacts with several nuclear receptors including estrogen and progesterone receptors in a ligand-dependent manner and enhances their transcriptional activity. AIB1 is amplified and overexpressed in >30% of breast cancers and can increase the sensitivity of breast cancer cells to estrogen and to growth factor signaling. BRCA1 regulates cell cycle progression, apoptosis induction, transcription, and DNA repair. From 5-10% of total breast cancers are due to germ-line BRCA1 mutations that lead to a deficiency in the BRCA1 protein. We have observed that AIB1 can partially reverse BRCA1 mediated repression of ERdependent transcriptional activity in breast cancer. This research will identify if there is a functional consequence of an interaction between AIB1 and BRCA1 in breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2006
Accession Number
ADA452446

Entities

People

  • John T. Lahusen

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Albumins
  • Antibodies
  • Biomedical Research
  • Biotechnology
  • Breast Cancer
  • Cell Line
  • Cells
  • Chromosomes
  • Estrogens
  • Gene Expression
  • Growth Factors
  • Hormones
  • Neoplasms
  • Progesterone
  • Proteins
  • Tissue Extracts
  • Tumor Cell Line

Fields of Study

  • Chemistry
  • Medicine

Readers

  • Gender and Food Studies
  • Molecular Biology and Genetics
  • Prostate Cancer Biology.

Technology Areas

  • Biotechnology