Analysis of Morphogenic Effect of hDAB2IP on Prostate Cancer and its Disease

Abstract

Prostate homeostasis is a balance between cell proliferation, apoptosis and differentiation in basal and luminal epithelia. It is believed that loss of homeostatic control in these cells renders the onset of neoplasm in prostatic epithelium. Until now, a little is known about homeostatic machinery in normal prostatic epithelium. In this project, we have proposed that DAB2IP protein, a novel RASGAP, is a part of homeostatic machinery and plays an important in modulating signal pathways elicited by exogenous growth/death stimuli. For example, DAB2IP is able to counteract androgen-mediated cell growth and is involved in TNF-alpha-mediated cell apoptosis. We further demonstrated that decreased steady-state levels of DAB2IP in normal prostatic epithelium resulted in the tumor formation of these cells. Further investigation has led us to unveil the underlying mechanism of DAB2IP in modulating specific signal cascades.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2006
Accession Number
ADA452524

Entities

People

  • Jer-Tsong Hsieh

Organizations

  • University of Texas at Dallas

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Androgens
  • Apoptosis
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Diseases And Disorders
  • Dna Sequence Analysis
  • Epithelium
  • Fibroblasts
  • Gene Expression
  • Genetics
  • Neoplasms
  • Prostate Cancer
  • Tissues

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Prostate Cancer Biology.