Potassium Channels in Neurofbromatosis-1
Abstract
Neurofibromatosis-1 (NF-1) is an autosomal dominant genetic disorder commonly associated with cognitive impairments, including low IQ, learning disabilities, behavioral difficulties, executive dysfunction and language-based deficits. Despite the growing recognition of the importance of SK channels in cognition, there has been no previous assessment of CNS SK channels in NF-1. We were the first to investigate potential mechanisms of cognitive impairment in NF-1 at the molecular level involving potassium channels, and demonstrated a possible mechanism for the learning deficits seen in NF1(+/-) mice and a possible drug therapy for rescuing these deficits. We anticipate that better understanding of this phenomenon will potentially lead to improved treatment of patients who are coqnitively impaired due to NF-1.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2006
- Accession Number
- ADA452531
Entities
People
- Mingkui Chen
Organizations
- University of Maryland, Baltimore