The Role of Tumor Metastases Suppressor Gene, Drg-1, in Breast Cancer
Abstract
The proposed research aims at elucidating the function of the tumor metastasis suppressor gene, Drg-1, in the hope that we can define a specific target for novel and effective therapies to prevent metastatic disease of breast cancer. During this funding period, our major effort has been focused on Task 2b, and we identified ATF3 as a down-stream target of Drg-1 by microarray analysis. This discovery of ATF3 gene has two important implications: firstly, it opened a new direction of our research for understanding the function of Drg-1 gene, and secondly, it suggests that ATF3 can be a potential therapeutic target for the treatment of metastatic disease. We also found that the expression of Drg-1 is significantly suppressed in breast tumor cells, and as we expected, the expression was inversely correlated with patient survival. Therefore, the expression of Drg-1 can serve as a good prognostic marker. We hope that we can clarify the relationship between PTEN and Drg-1 in more detail in both 'in vitro' and 'in vivo' in the next fiscal year.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2006
- Accession Number
- ADA452685
Entities
People
- Kounosuke Watabe
Organizations
- Southern Illinois University