Testosterone Correlates with Venezuelan Equine Encephalitis Virus in Macaques
Abstract
Here we briefly report testosterone and cytokine responses to Venezuelan equine encephalitis virus (VEEV) in macaques which were used as part of a larger study conducted by the Department of Defense to better characterize pathological responses to aerosolized VEEV in non-human primates. Serial samples were collected and analyzed for testosterone and cytokines prior to and during infection in 8 captive male macaques. Infected animals exhibited a febrile response with few significant changes in cytokine levels. Baseline testosterone levels were positively associated with viremia following exposure and were significantly higher than levels obtained during infection. Such findings suggest that disease-induced androgen suppression is a reasonable area for future study. Decreased androgen levels during physiological perturbations may function, in part, to prevent immunosuppression by high testosterone levels and to prevent the use of energetic resources for metabolically-expensive anabolic functions.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 29, 2006
- Accession Number
- ADA452693
Entities
People
- Frank B. Cogswell
- George V. Ludwig
- James Koterski
- Mark A. James
- Michael P. Muehlenbein
Organizations
- University of Wisconsin–Milwaukee