Metallic Nanoprobes for Enhanced Raman and Fluorescence Spectroscopy

Abstract

Metallic Nanoprobe Fabrication: Current approaches include deposition of metal island films on substrates and salt-induced aggregation of metallic colloids; good enhancement is observed but reproducibility is a serious issue; variability in nanoprobe fabrication is responsible for assay variability. Our approach is to synthesize metallic nanosphere structures with controlled interparticle spacing to exploit significant field enhancement between particles; start with simplest structure nanosphere dimer; dimers permit fully solution-based assay.

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Document Details

Document Type
Technical Report
Publication Date
Nov 18, 2003
Accession Number
ADA453066

Entities

People

  • Mitchell R. Zakin

Organizations

  • Physical Sciences (United States)

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Aqueous Solutions
  • Cell Physiological Processes
  • Cytochromes
  • Electromagnetic Fields
  • Fluorescence
  • Fluorophores
  • Hot Spots
  • Metallic Nanoparticles
  • Particles
  • Quantum Yields
  • Raman Scattering
  • Raman Spectra
  • Raman Spectroscopy
  • Scattering
  • Spectra
  • Spectroscopy
  • Tissue Extracts

Fields of Study

  • Chemistry
  • Physics

Readers

  • Computational Modeling and Simulation
  • Nanocomposite Materials Science
  • Nanoscale Plasmonic Nanotechnology

Technology Areas

  • Space