Long-Term Efficacy of Routine Access to Antiretrovial-Resistance Testing in HIV Type 1-Infected Patients: Results of the Clinical Efficacy of Resistance Testing Trial
Abstract
The long-term efficacy of making resistance testing routinely available to clinicians has not been established. We conducted a clinical trial at 6 US military hospitals in which volunteers infected with human immunodeficiency virus type 1 were randomized to have routine access to phenotype resistance testing (PT arm), access to genotype resistance testing (GT arm), or no access to either test (VB arm). The primary outcome measure was time to persistent treatment failure despite change(s) in antiretroviral therapy (ART) regimen. Overall, routine access to resistance testing did not significantly increase the time to end point. Time to end point was significantly prolonged in the PT arm for subjects with a history of treatment with 4 different ART regimens or a history of treatment with nonnucleoside reverse-transcriptase inhibitors before the study, compared with that in the VB arm. These results suggest that routine access to resistance testing can improve long-term virologic outcomes in HIV-infected patients who are treatment experienced but may not impact outcome in patients who are naive to or have had limited experience with ART.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 06, 2004
- Accession Number
- ADA453074
Entities
People
- Cindy Tamminga
- David L. Blazes
- Kevin T. Stephan
- Mark R. Wallace
- Matthew J. Dolan
- Naomi E. Aronson
- Nelson Michael
- Scott A. Wegner
- Susan Fraser
- Sybil A. Tasker
Organizations
- Naval Submarine Medical Research Laboratory