Effect of JP-8 Vehicle on Dermal Penetration of Hydrocarbon Components from Jet Fuel

Abstract

Published data on the dermal penetration of hydrocarbon components from the widely used jet fuel JP-8 are analyzed. The log of the dermal penetration coefficient Kp was observed to have a linear dependence on lipophilicity as estimated from the log-octanol-water partition coefficient Ko/w (with slight dependence on molecular weight). This semi-empirical relation can be used to predict (estimate) Kp values for other JP-8 components. In contrast to the penetration of compounds form aqueous vehicle, the more lipophilic compounds penetrated the skin at a lower rate, consistent with results on the partitioning of compounds into the stratum corneum from different vehicles.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2000
Accession Number
ADA453171

Entities

People

  • J. Mcdougal
  • P. Robinson

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Air Force Research Laboratories
  • Alkanes
  • Chemical Properties
  • Chemistry
  • Coefficients
  • Epidermis
  • Fuels
  • Government Procurement
  • Governments
  • Hydrocarbons
  • Jet Engine Fuels
  • Materials
  • Military Research
  • Molecular Weight
  • Risk Analysis
  • Skin

Readers

  • Petroleum Engineering
  • Regression Analysis.
  • Toxicology/Environmental Toxicology