Inhibitors of Histone Deacetylases for Radiosensitization of Prostate Cancer

Abstract

Failure of conventional treatment of prostate cancer with radiotherapy may be due to intrinsic resistance of the tumor cells. One of mechanisms underlying intrinsic radiation sensitivity is linked to the state of chromatin architecture. The long-term goal of this proposal is to develop a novel therapeutic strategy by enhancing radiosensitivity of prostate cancer cells by testing the hypothesis that an increase of cellular radiation sensitivity may be achieved by exposure of cells to specific HDAC inhibitors. During the second year of the research funding period, the major accomplishment and significance of the research include:(1) siRNA HDAC isoform transfection and determination of efficacy of siRNA HDAC isoforms on cellular radiation sensitivity. (2) Determination of gene expression profiling regulated by HDAC inhibitor, TSA, and by HDAC isoforms.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2006
Accession Number
ADA453405

Entities

People

  • Mira O. Jung

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Data Mining
  • Enzyme Inhibitors
  • Gene Expression
  • Inhibitors
  • Prostate
  • Prostate Cancer
  • Proteins
  • Radiation
  • Sensitivity
  • Targets
  • Transfection

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Nuclear and Radiation Engineering.
  • Oncology