Global Analysis of Transcript and Protein Levels Across the Plasmodium falciparum Life Cycle

Abstract

To investigate the role of post-transcriptional controls in the regulation of protein expression for the malaria parasite, Plasmodium falciparum, we have compared mRNA transcript and protein abundance levels for seven different stages of the parasite life cycle. A moderately high positive relationship between mRNA and protein abundance was observed for these stages; the most common discrepancy was a delay between mRNA and protein accumulation. Potentially post-transcriptionally regulated genes are identified, and families of functionally related genes were observed to share similar patterns of mRNA and protein accumulation.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2004
Accession Number
ADA453474

Entities

People

  • Anthony A. Holder
  • Audrey Santrosyan
  • Daniel J. Carucci
  • Jeffrey R. Johnson
  • John R. Yates Iii
  • Karine G. Leroch
  • Kim C Williamson
  • Laurence Florens
  • Munira Grainger
  • S. F. Yan
  • Yingyao Zhou

Organizations

  • Scripps Research

Tags

DTIC Thesaurus Topics

  • Antigens
  • Biomedical And Dental Materials
  • Carrier Proteins
  • Cells
  • Chemistry
  • Data Sets
  • Dna Microarrays
  • Eukaryotes
  • Gene Expression
  • Life Cycles
  • Malaria
  • Parasites
  • Polymeric Films
  • Proteins
  • Proteomics
  • Rna Stability
  • Spores

Fields of Study

  • Biology

Readers

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  • Parasitology and Pharmacology of Malaria.