Acute Lung Injury Following Smoke Inhalation: Predictive Value of Sputum Biomarkers and Time Course of Lung Inflammation
Abstract
The role of lung inflammatory mediators in the development of lung injury following smoke inhalation is unknown. To evaluate the predictive value and role of inflammatory mediators in acute lung injury following smoke inhalation. Specific aims: 1) Determine the predictive value of initial inflammatory markers in bronchial secretions of smoke inhalation victims for subsequent lung injury. 2) Measure longitudinal changes in inflammatory mediators in smoke inhalation victims. Study design: Bronchial secretions from 200-250 intubated patients with smoke inhalation injury will be evaluated for initial and longitudinal changes concentrations of substance P, TNF-alpha, IL-1, IL-8, and IL-10, as well as cell count and differential every two hours to a maximum of 72 hours. Initial lung inflammation and changes in inflammatory markers will be compared in patients without and without subsequent significant lung injury. Progress to date: We have enrolled 95 subjects to date and analyzed 23-32 subjects with for TNF-alpha, IL-1, IL-8, IL-10, sFASl, substance P, IL-1RA, alpha2M, MMP-9, and TIMP-1 concentrations. We have found temporal changes in IL-8 and IL-1beta, and a significant relation between low initial IL-8 and risk of ALI. Further analysis of the concentrations of biomarkers predictive of the severity of subsequent lung injury await completion of recruitment.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2006
- Accession Number
- ADA454001
Entities
People
- Jefferey L. Burgess
Organizations
- University of Arizona