Non-Invasive Monitoring for Optimization of Therapeutic Drug Delivery by Biodegradable Fiber to Prostate Tumor
Abstract
Chemotherapeutic Drugs delivered by systematic administration exhibit great toxicity; patients have to endure suffering from frequent injection or low dose IV treatment. Thus controlled release of these drugs will be a treatment modality. Moreover, realtime monitoring of the effects of the drug by sensing the dynamic response of the tumor to a particular drug can significantly enhance the therapeutic outcome. The Hypotheses are (1): A near-infrared (NIR) imager can non-invasively monitor the dynamic and chronic distribution of the chemotherapeutic drug, vascular oxygenation, and blood volumes in prostate tumors. (2): The dynamic response of prostate tumor oxygenation to the chronic drug delivery can serve as indicator for treatment prognosis. The Specific Aims are: (1): To design and implement a NIR spectroscopic imaging system (2): To develop 2D tomographic imaging of drug concentration and tumor oxygenation. (3): to control the delivery of drug and (4): to study the relationship between drug release rate, tumor oxygen levels and therapeutic outcome.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2006
- Accession Number
- ADA454849
Entities
People
- Dan Popa
- Hanli Liu
- Liping Tang
Organizations
- University of Texas at Arlington