Vasculature-Specific Adenovirus Vectors for Gene Therapy of Prostate Cancer

Abstract

In Year 2 of the project we have completed Task 2 (as per approved Statement of Work) by characterizing the binding specificity of the Ad fiber proteins designed to bind IL-11Ralpha. In Task 3 of the project we identified the most promising fiber ligand constructs and designed Ad genomes that incorporate the genes for these proteins in addition to the reporter expressing gene cassettes.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2006
Accession Number
ADA454851

Entities

People

  • Victor Krasnykh

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Adenoviruses
  • Biomedical Research
  • Biotechnology
  • Blood Vessels
  • Cassettes
  • Cell Line
  • Cells
  • Endothelial Cells
  • Gene Therapy
  • Genetic Engineering
  • Health Services
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Therapy
  • Viruses

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Technical Research and Report Writing.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech