Genetic Epidemiology of Prostate Cancer

Abstract

Prostate cancer results from complex interactions among genetic, endocrine, and environmental factors. Understanding genetic risk factors that contribute to the occurrence of prostate cancer is crucial to design both preventative and therapeutic strategies and to identify at-risk individuals. This knowledge could reduce the incidence of and death from this disease. The primary objective of this grant is to investigate changes in genes that directly and indirectly regulate levels of male hormones, which in turn, affect prostate cell growth, and may ultimately cause cancer. In this past 8 months, we have genotyped the DNA samples for eight haplotype-tagging SNPs in IGF1, an additional ten SNPs in IGF1R,one additional SNP in IRS1 and three additional SNPs in IGFBP3, as well as performed genotyping of the SRD5A2 V89L and CYP3A4 B1 polymorphisms from the original proposal. We have performed statistical analysis of the 18 IGF1R SNPs and the PI3KCB and SHC1 SNPs. Two of the IGF1R SNPs were significantly associated with Gleason score. More analyses are in progress.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2006
Accession Number
ADA454886

Entities

People

  • Susan L. Neuhausen

Organizations

  • University of California, Irvine

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • California
  • Diseases And Disorders
  • Epidemiology
  • Ethnic Groups
  • Genes
  • Genetic Variation
  • Genetics
  • Genotypes
  • Growth Factors
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Risk Factors
  • Statistical Analysis
  • United States

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology