Radiation Sensitization Via Inhibiting Survival of Prostate Cancer and its Vascular Endothelium

Abstract

We have proposed that Akt/mTOR signaling mediates cell survival and contributes to radioresistance. We intend to investigate the cellular and molecular mechanism by which inhibition of Akt/mTOR or overexpression of PTEN in both prostate cancer and its vasculature results in radiosensitization. In addition, we propose to determine possible association between level or activity of these molecules and clinical response to radiotherapy. We have found that irradiation activates Akt/mTOR signaling and combination of radiation and mTOR inhibitors enhances anti-angiogenic effects of irradiation via upregulation of apoptosis. We will investigate the interaction of Akt, Pten and mTOR and its relevance in the targeted therapeutics of prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2005
Accession Number
ADA454896

Entities

People

  • Bo Lu

Organizations

  • Vanderbilt University

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Apoptosis
  • Biological Sciences
  • Cell Physiological Processes
  • Endothelium
  • Inhibition
  • Inhibitors
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Radiation
  • Radiotherapy
  • Survival
  • Therapy
  • Vascular Endothelium

Fields of Study

  • Biology
  • Medicine
  • Physics

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular Biology and Genetics
  • Prostate Cancer Biology.