Radiation-Induced Immune Modulation in Prostate Cancer
Abstract
This proposal is to determine if radiation affects presentation of prostate specific antigen (PSA) through endogenous and exogenous pathways by dendritic cells (DOs) and to devise strategies to enhance the manner in which radiation-induced cell death is translated into the generation of tumor-specific immunity so as to achieve the best therapeutic outcome from radiation therapy. From the conventional point of view radiotherapy is usually related to cell killing. However our hypothesis is that radiation is more than just depleting cells. It also influences functional antigen presentation by DOs without killing them. We chose PSA as antigen for this study but because of the high risk nature of the experiments and the high PSA expression levels in prostate cancer patients we have also explored the possibility of monitoring the immune responses to the antigen surviving in prostate cancer. Our approach to translate radiation-induced immunosuppression into beneficial tumor immunogenicity focuses on IL-3 and/or GM-OSF treatment. Our studies on combined treatment of radiotherapy and IL-3 and on the effects of radiation on PSA presentation by DOs are underway and are presented in this Progress Report along with other milestone that have been attained.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2006
- Accession Number
- ADA454929
Entities
People
- William H. Mcbride
Organizations
- University of California, Los Angeles