A Stochastic Model Providing a Rationale for Adjuvant Chemotherapy

Abstract

A model yielding the probability of curative outcome for a patient at the time of tumor detection is presented the status of the patient is determined by whether or not metastases (distant spread of the tumor) have occurred and whether any such metastases are drug resistant. If there are no metastases, then local excision is presumed curative; if there are nonresistant metastases, then local excision plus adjuvant chemotherapy is presumed curative; if any metastases are drug resistant, there is no cure. Metastases and drug resistance arise independently with intensities proportional to total tumor size. Over a wide range of such intensities, the addition of adjuvant drug therapy yields a dramatic improvement in the probability of cure.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1986
Accession Number
ADA455199

Entities

People

  • Barry W. Brown
  • James R. Thompson

Organizations

  • Rice University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Applied Mathematics
  • Chemotherapy
  • Drug Resistance
  • Drug Therapy
  • Excision
  • Health Services
  • Information Operations
  • Intensity
  • Mathematics
  • Probability
  • Therapy

Readers

  • Prostate Cancer Biology.
  • Statistical inference.
  • Trauma Surgery or Emergency Medicine.