Effect of Nifedipine on Core Cooling in Rats during Tail Cold Water Immersion
Abstract
Male rats (450 g, n=11/group) were heated at an ambient temperature of 42 degrees C until a rectal temperature of 42.8 degrees C was attained. The rats then received either saline (30 degrees C) + tail ice water immersion (F + I) or saline (30 degrees C) + tail ice water immersion + Nifedipine, a peripheral vasodilator (F + I + N) to determine cooling rate effectiveness and survivability. The time it took for the rats to reach a rectal temperature of 42.8 degrees C averaged 172 minutes in both groups, resulting in similar heating rates (0.029 degrees C/minute). The cooling rates in group F + I and F + I + N were not significantly different from each other. The authors conclude that since Nifedipine did not improve cooling rates when combined with fluid + tail ice water immersion, its use as a cooling adjunct does not seem warranted.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2003
- Accession Number
- ADA455316
Entities
People
- Lawrence De Garavilla
- Michael J. Durkot
Organizations
- United States Army Research Institute of Environmental Medicine