Analysis of the Role of the Wnt/Beta-Catenin Pathway in Prostate Development and Tumorigenesis
Abstract
We have continued studies which are focused on understanding how dysregulation of the Wnt/B-catenin signaling pathway are causally associated with prostate tumorigenesis. We have created a mouse model in which B-catenin signaling is activated and found that these mice develop prostate tumors with 100% penetrance. This process initiates with small areas of prostatic hyperplasia as early as 4.5 weeks of age, continues on to lesions resembling prostatic intraepithelial neoplasia (PIN), and progresses to invasive prostate carcinoma by 7 months of age. We have examined these mice at older ages and found that these tumors do not appear to metastasize. In addition, we have found that these tumors are initially androgen sensitive, based on the apoptotic response of these tumors to surgical castration, however, mice examined five months after castration reveal small areas of hyperplasia occurring in an androgen-independent manner. Finally, we are embarking on studies to determine if activation of B-catenin signaling can synergize with other genetic lesions in prostate cancer progression.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2006
- Accession Number
- ADA455352
Entities
People
- Bart O. Williams