A Novel Therapy System for the Treatment of Occult Prostate Cancer

Abstract

The goal of this research was to investigate efficacy and mechanisms of H5BVIFN- , a novel immunotherapeutic agent, against prostate cancer in animal models. The objectives in year 2 were to determine efficacy of a mixture of irradiated TRAMP-L5 mouse prostate cancer cells and lyophilized H5BVIFN- in regressing orthotopic tumors of TRAMP-L5 cells and to study effects of intratumoral injection of H5BVIFN- on expression of immune stimulatory cytokine in tumors. We found that subcutaneous injections of irradiated TRAMP-L5 cells, recombinant IFN- , or H5BVIFN- , partially inhibited orthotopic growth of TRAMP-L5 cells in syngeneic mice. An additive inhibitory effect was observed in mice injected with a mixture of irradiated TRAMP-L5 cells and H5BVIFN- . However, none of the therapies was able to eradicate orthotopic tumors. Intratumoral delivery of H5BVIFN- was not able to enhance expression of immunestimulatory cytokines interleukin (IL)-2, IL-12, or interferon-Y.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2006
Accession Number
ADA455776

Entities

People

  • Zhongyun Dong

Organizations

  • University of Cincinnati

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Antigens
  • Biological Sciences
  • Biomedical Research
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Cytokines
  • Department Of Defense
  • Electronic Mail
  • Endothelial Cells
  • Molecules
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Survival
  • Therapy

Fields of Study

  • Medicine

Readers

  • Immunology
  • Nuclear and Radiation Engineering.
  • Oncology (Cancer Research).