Cellular Retinoic Acid Binding Protein and Breast Cancer

Abstract

In attempts to understand how the signaling by retinoic acid (the active vitamin A metabolite) is regulated we have been studying the retinoic acid binding protein called CRABP-II. These studies revealed that CRABP-II acts to enhance the transcriptional activities of RA and that it does so by directly delivering the hormone to its cognate transcription factor, RAR. Consequently CRABP-II dramatically sensitized cultured mammary carcinoma cells to RA-induced growth inhibition. Similarly, over-expression of CRABP-II inhibited mammary tumor growth in two different mouse models of cancer. CRABP-II may be a novel target for therapeutic and preventive strategies for retinoid-treatment of breast cancer. This project aims to delineate the mechanism by which CRABP-II modulates RA activity, especially as related to its ability to enhance the anti-proliferative action of the ligand.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
May 01, 2006
Accession Number
ADA455778

Entities

People

  • Leslie J. Donato

Organizations

  • Cornell University

Tags

DTIC Thesaurus Topics

  • Acids
  • Apoptosis
  • Breast Cancer
  • Carrier Proteins
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Enzyme Inhibitors
  • Neoplasms
  • Programmed Cell Death
  • Proteins
  • Retinoic Acids
  • Rna Stability
  • Transcription Factors
  • Tumor Cell Line

Fields of Study

  • Biology
  • Chemistry

Readers

  • Breast cancer cell signaling and growth regulation.
  • Computer Programming and Software Development.