BRCA1 Protein Complexes: Dynamic Changes and Functions Important in Breast Cancer

Abstract

In the past year, I have made substantial progress towards completion of the tasks outlined in my Statement of Work. I have continued to study the intrinsic transcriptional activity of BRCA1 in the fully purified system, and I have described distinct mechanisms for transcriptional stimulation and repression. These activities recapitulate the in vivo transcriptional functions of BRCA1.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2006
Accession Number
ADA455789

Entities

People

  • Andrew Horwitz

Organizations

  • Harvard Medical School

Tags

DTIC Thesaurus Topics

  • Albumins
  • Biomedical And Dental Materials
  • Biomedical Research
  • Breast Cancer
  • Carrier Proteins
  • Cell Line
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Molecular Biology
  • Neoplasms
  • Polymer Chemistry
  • Polymeric Films
  • Proteins
  • Proteomics
  • Transcription Factors

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Technical Research and Report Writing.