Stimulation of Estrogen Receptor Signaling in Breast Cancer by a Novel Chaperone Synuclein Gamma
Abstract
The association between SNCG expression and the progression of steroid dependent cancers of breast and ovary promoted us to investigate the role of SNCG in regulation of ER . SNCG strongly stimulated the ligand-dependent transcriptional activity of ER in breast cancer cells. A notable finding relevant to this study is that SNCG, acting as a chaperone for ER, strongly stimulated the ligand-dependent transcriptional activity of ER , ligand-dependent cell growth, and ligand-dependent mammary tumorigenesis. Augmentation of SNCG expression stimulated the transcriptional activity of ER and ligand-dependent growth, whereas compromising endogenous SNCG expression suppressed ER signaling and ligand-dependent growth.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2005
- Accession Number
- ADA455854
Entities
People
- Y. E. Shi
Organizations
- North Shore University Hospital