Targeting MRS-Defined Dominant Intraprostatic Lesions with Inverse-Planned High Dose Rate Brachytherapy

Abstract

During this second year, we have obtained CHR approval (December 2004) from the three step process (G.U., P.R.C. and C.H.R.) committees at UCSF. Patient enrollment will begin immediately after receiving CHR approval from D.O.D. We have developed a deformable image registration method to improve the quality of registration of (probe-in) MRS data for (probe-out) radiation treatment planning. A similarity index (SI) of 98.1% was obtained for rigid probe patient data. We have also obtained a class solution for the boost of DIL defined by MRI/ MRSI, as well as for the sparing of organs at risk including bladder, rectum, urethra and penile bulb.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2006
Accession Number
ADA456012

Entities

People

  • Jean Pouliot

Organizations

  • University of San Francisco

Tags

DTIC Thesaurus Topics

  • Accuracy
  • Algorithms
  • Biomedical Research
  • Department Of Defense
  • Distortion
  • Dose Rate
  • Grids
  • Image Registration
  • Magnetic Resonance
  • Neoplasms
  • Oncology
  • Prostate Cancer
  • Radiation
  • Radiotherapy
  • Side Effects
  • Three Dimensional
  • Two Dimensional

Fields of Study

  • Medicine
  • Physics

Readers

  • Clinical Trial Research.
  • Medical Imaging.