Novel Micro/Nano Approaches for Glucose Measurement Using pH-Sensitive
Abstract
This project aims to couple environmentally-sensitive hydrogel materials with immobilized enzymes and two novel readout techniques to develop general platforms for biosensing. The need for improved testing methods for diabetics as well as the potential for use of glucose level as a general marker of metabolic status is the primary motivation for this work. This project is focusing on the use of sensitive transduction schemes that allow reliable detection of small physical/mechanical changes in gel size or water content, specifically: microelectromechanical systems (MEMS) and fluorescence resonance energy transfer (RET) optical systems. Successful demonstrations of glucose sensing have been accomplished in both areas, and interesting discoveries of hydrogel structure and properties have been uncovered using the novel measurement approaches. The project has generated three published manuscripts and four conference reports.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2006
- Accession Number
- ADA456401
Entities
People
- Mike Mcshane
Organizations
- Louisiana Tech University