Targeting of an Antimetastatic and Antiangiogenic Compound to Breast Tumors
Abstract
Anastellin is a fragment of fibronectin which inhibits angiogenesis, tumor growth, and metastasis in vivo, but the mechanisms behind these effects were previously unknown. We have shown that anastellin co-localizes with Annexin V, a marker for anionic phospholipids on the surface of tumor blood vessels in vivo. Anastellin potentially uses the increased levels of phosphatidylserine on the surface of proliferating endothelial cells in angiogenic blood vessels to bind to the membrane and lyse the cell, leading to its anti-angiogenic effect in tumors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2006
- Accession Number
- ADA456896
Entities
People
- David Peters
Organizations
- Sanford Burnham Prebys Medical Discovery Institute