Effect of HER-2/NEU Signaling on Sensitivity to Trail in Prostate Cancer

Abstract

The long-term goal of our research project is to develop a novel therapy for HER-2/neu overexpressing prostate cancer. Previous studies have shown that the HER-2/neu homodimer constitutively activates the PI(3)K-Akt-NF-kB single transduction pathway. In this budget period, we examined whether quercetin, a P13K inhibitor, promotes TRAIL cytotoxicity by inhibiting Akt activity. As DU-145 cells were treated with quercetin, we observed that TRAIL-induced cytotoxicity was promoted.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2006
Accession Number
ADA456903

Entities

People

  • Yong J Lee

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Department Of Defense
  • Electronic Mail
  • Information Operations
  • Maryland
  • Neoplasms
  • Pennsylvania
  • Prostate
  • Prostate Cancer
  • Sensitivity
  • Universities

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular and Cellular Biochemistry
  • Oncology (Cancer Research).