The Role of C-FLIP(L) in Regulating Apoptotic Pathways in Prostate Cancer

Abstract

Abnormalities in programmed cell death (apoptosis) machinery play a crucial role in the initiation, progression, and metastasis of prostate cancer. Therefore, molecules that initiate pro-apoptotic pathways are excellent therapeutic agents in prostate cancer. However, some prostate cancer cells develop resistance to pro-apoptotic agents. In this proposal, the authors are examining the regulatory mechanisms of c-FLIP(L), which is an important modulator of apoptosis in prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2005
Accession Number
ADA456986

Entities

People

  • Aria F. Olumi

Organizations

  • Beth Israel Deaconess Medical Center

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biomedical Research
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Clinical Trials
  • Computer Programs
  • Epithelial Cells
  • Families (Human)
  • Gene Expression
  • Genetic Code
  • Molecules
  • Neoplasms
  • Programmed Cell Death
  • Prostate
  • Prostate Cancer
  • Tissues

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Prostate Cancer Biology.