Angiogenic Signaling in Living Breast Tumor Models
Abstract
In this grant we propose to elucidate the signaling pathway that translates VEGFR activation into elevated vessel permeability, in endothelial cells within living breast tumor models. The working hypothesis is that the signaling pathway involved is a constitutively active form of the pathway shown for healthy mesenteric microvessels. Progress to date includes the recruitment of personnel to the new laboratory, the development and testing of a novel method for the measurement of convective flow in tumors in vivo, the investigation of second harmonic generation as a reproducible measure of photodamage in tissue during diffusion and permeability measurements, and preliminary experiments to evaluate methodology for tasks to commence in upcoming years.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2006
- Accession Number
- ADA457030
Entities
People
- Edward B Brown
Organizations
- University of Rochester