Breast Cancer Therapy With Annexin 11 Nanoparticles
Abstract
The long-term goal of our research program is to identify the key molecular events that lead to development and progression of breast cancer, in order that improved therapies to treat this disease can be developed. The objective of studies outlined in this proposal is to determine if sustained inhibition of annexin II prevents breast cancer cell growth and angiogenesis. During the performance period of this grant, we have developed a novel nanotechnology mediated vector (nanoparticles) for delivering a novel protein annexin II. We show that nanoparticle mediated delivery of human annexin II inhibitory RNA results in reduced cell proliferation and cell migration. Future studies should be aimed at testing the ability of these sustained release nanoparticles on reducing breast cancer tumors in an animal model system.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2006
- Accession Number
- ADA457045
Entities
People
- Jamboor Vishwanatha
Organizations
- University of North Texas Health Science Center