The Role of Siah1-Induced Degradation of Beta-Catenin in Androgen Receptor

Abstract

The androgen receptor (AR) signaling-pathway plays crucial roles in the growth and progression of prostate cancer cells. Recent studies indicate that Beta-Catenin physically binds to AR and enhances its transcriptional activity in a ligand-dependent manner. P53 also has been implicated in AR signaling because of its ability to induce expression of Siah1, which binds and activates E3 ligase complexes that degrade Beta-Catenin. In this study, the authors demonstrated the biological significance and molecular mechanisms by which AR is regulated by the p53-induced Siah1 protein. Moreover, they identified the relevant proteins that are targeted for degradation by Siah1 besides Beta-Catenin. Thus, enhanced Siah function may suppress the ability of androgen to promote tumor cell growth. Understanding more about the functions of Siah-family proteins may therefore suggest novel strategies for chemoprevention and for improved treatment of prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2005
Accession Number
ADA457050

Entities

People

  • Shu-ichi Matsuzawa

Organizations

  • Sanford Burnham Prebys Medical Discovery Institute

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Antibodies
  • Biomedical Research
  • Carrier Proteins
  • Cell Line
  • Cells
  • Coding
  • Degradation
  • Epithelial Cells
  • Genetic Structures
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Sequences

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology