Efficacy of rSEB Vaccine and CpG ODN Administered by Inhalation in Monkeys
Abstract
Introduction/concept: Staphylococcal enterotoxins (SEs) family of exotoxins (23-29 kDa) produced Staphylococcus aureus categorized as a superantigen stimulate T cells release of cytokines (e.g., interferon- , IL-6 and TNF- ) " Primates/humans very sensitive to SEB due to MHC class II binding affinities " MHC polymorphisms within human populations contributes to individual differences in susceptibility to the effects of SEB Inbred mice differ in MHC alleles results in varying sensitivities to SEB rodents are not very susceptible " A recombinant SEB vaccine (rSEBv) developed at USAMRIID protected both rodents and nonhuman primates from lethal aerosols of SEB enteric effects observed in vaccinees May stem from lack of mucosal immunity against SEB Both systemic and mucosal immunity is thought to be important when protecting against SEB A proteosome-toxoid SEB vaccine admin. mucosally to monkeys resulted in 100% protection against SEB aerosol challenge and an overall reduction of enteric effects, " this observation was not quantifiable (Lowell et al., 1996).
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 19, 2003
- Accession Number
- ADA457234
Entities
People
- Chad J Roy
Organizations
- United States Army Medical Research Institute of Infectious Diseases