Metal Cation Mediated Hydrolysis of Phosphono-Formate Diesters: Chemoselectivity and Catalysis

Abstract

SUMMARY: 1 . Ce4+, Th4+ , Zr4+, and Hf4+ ions accelerate the hydrolysis of phosphonoformate diesters. 2. With identical C-OR and P-OR leaving groups, Zr4+ and Hf4+ direct scission to the P-O ester site, whereas Ce4+ and Th4+ mediate attack at the C-O site. 3 . Leaving group efficiency (PhO > MeO) can modulate the chemoselectivity. 4 . P-O selectivity is associated with tetrameric or octameric forms of Zr4+ or Hf4+ aqueous complexes . 5. C-O selectivity is associated with dinuclear or mononuclear forms of Ce4+ or Th4+.

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Document Details

Document Type
Technical Report
Publication Date
Nov 19, 2003
Accession Number
ADA457240

Entities

People

  • Hugo Morales-rojas
  • Robert A. Moss
  • Saketh Viayaraghavan

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  • Rutgers University–New Brunswick

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